Jemperli is a prescription medicine used to treat adults with certain cancers that have been shown by a laboratory test to be mismatch repair deficient (dMMR), and your cancer has returned, or it has spread or cannot be removed by surgery (advanced cancer). Jemperli may be used when:
you have a kind of uterine cancer called endometrial cancer, and you have received chemotherapy that contains platinum and it did not work or is no longer working.
you have a solid tumor that progressed during treatment or after treatment, and you have no satisfactory treatment options.
Your healthcare provider will give you Jemperli into your vein through an intravenous (IV) line over 30 minutes.
Jemperli is usually given every 3 weeks for the first 4 doses, and then beginning 3 weeks later, it is usually given every 6 weeks.
Your healthcare provider will decide how many treatments you need.
Your healthcare provider will do blood tests to check you for side effects.
If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.
Precaution & Warnings:
Jemperli is a medicine that may treat certain cancers by working with your immune system.
Jemperli can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended.
Call or see your healthcare provider right away if you develop any symptoms of the following problems or if these symptoms get worse:
Lung problems (pneumonitis). Symptoms of pneumonitis may include:
new or worsening cough
shortness of breath
Intestinal problems (colitis) that can lead to tears or holes in your intestine. Signs and symptoms of colitis may include:
diarrhea or more bowel movements than usual
stools that are black, tarry, sticky, or have blood or mucus
severe stomach-area (abdomen) pain or tenderness
Liver problems, including hepatitis. Signs and symptoms of liver problems may include:
yellowing of your skin or the whites of your eyes
nausea or vomiting
pain on the right side of your stomach area (abdomen)
dark urine (tea colored)
bleeding or bruising more easily than normal
Hormone gland problems (especially the adrenal glands, pituitary, thyroid, and pancreas). Signs and symptoms that your hormone glands are not working properly may include:
headaches that will not go away or unusual headaches
dizziness and fainting
weight gain or weight loss
feeling more hungry or thirsty than usual
changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
your voice gets deeper
very low blood pressure
urinating more often than usual
nausea and vomiting
stomach-area (abdomen) pain
Kidney problems, including nephritis and kidney failure. Signs of kidney problems may include:
change in the amount or color of your urine
blood in your urine
swelling in your ankles
loss of appetite
Skin problems. Signs of skin problems may include:
fever or flu-like symptoms
swollen lymph nodes
blisters, peeling, or skin sores
painful sores or ulcers in your mouth or in your nose, throat, or genital area
Problems in other organs. Signs and symptoms of these problems may include:
tiredness or weakness
changes in heartbeat, such as beating fast, or seeming to skip a beat, or pounding sensation
confusion, fever, muscle weakness, balance problems, nausea, vomiting, stiff neck, memory problems, or seizures (encephalitis)
swollen lymph nodes, rash or tender lumps on skin, cough, shortness of breath, vision changes, or eye pain (sarcoidosis)
seeing or hearing things that are not there (hallucinations)
severe or persistent muscle pain
severe muscle weakness
low red blood cells (anemia)
low white blood cell counts
bruises on the skin or bleeding
changes in eyesight
Infusion reactions that can sometimes be severe and life-threatening. Signs and symptoms of infusion reactions may include:
chills or shaking
shortness of breath or wheezing
itching or rash
feeling like passing out
Proper doctor prescription is needed.
*Note: The prescription should not be older than 6 month.
Other drugs may interact with dostarlimab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.