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Ventricular Septal Defect (VSD)

“A Ventricular Septal Defect (VSD) is often referred to as a hole in the heart. This condition may generally occur at the time of birth. In this congenital defect, the wall or the septum dividing the lower chambers of the heart, the ventricles, is not completely formed, leaving a gap or a hole. This hole allows some of the blood from the left ventricle to pass into the right side of the heart. The left ventricle, in fact, has oxygen-rich blood that must be supplied to the rest of the body. However, due to this hole, it gets pumped back to the lungs making the heart work harder to pump this extra blood all over again.

A small ventricular septal defect may cause no problems, and many small VSDs close on their own. Medium or large VSDs may need surgical repair early in life to prevent complications.

A ventricular septal defect (VSD) is generally a condition since birth. Genetic or inherited diseases such as Down’s syndrome is also associated with ventricular septal defect (VSD). There are certain diseases that pregnant women could be exposed to, which can be a cause for ventricular septal defect (VSD) in the unborn children. Other reasons could include some prescription medications, rubella (German measles) and/or uncontrolled diabetes.

Symptoms of Ventricular Septal Defect (VSD)

The most common symptoms of the ventricular septal defect (VSD) are as follows:

Getting short of breath especially while exercising
Exhaustion/ tiredness
Cyanosis (a blue tint on the lips, skin, or fingernails caused by a lack of oxygen)
Murmuring of the heart
Abnormality in the rhythms of the heart. Also known as arrhythmias
Extremities getting swollen
There is a possibility that most of the above-mentioned symptoms can be misinterpreted to be some other disease altogether. It could be perceived that it is some sort of lung disorder or the generic signs of aging or physical inactivity.

Treatment of Ventricular Septal Defect (VSD)

There are a variety of procedures that can be followed to treat or manage ventricular septal defect (VSD), depending upon its severity.

Observation

Certain minor congenital heart defects found in adults will not require any treatment as such. However, these patients must enrol themselves for regular heart check-ups to ensure that the defect is not getting more severe over time.

Drug Therapies

Medicines can be used to treat some minor septal defects in order to help the heart work better. These drugs are given to achieve the following results:

Lower the pace of a heartbeat (beta-blockers)
Relax the blood vessels (calcium channel blockers)
Prevention of blood clots such as warfarin
Discharge excessive fluids from the body (diuretics)
Not all drugs can have the same response for all types of ventricular septal defects. There is a possibility that some drugs that are useful in treating a specific type of septal defect can make another type of septal defect worse.

Patients suffering from ventricular septal defect (VSD) are always at a risk of infection, known as endocarditis. This is still possible even if their defect has been completely cured.

Surgery for Correction of VSD

Before the heart surgery

Certain pre-operative tests will be conducted before the surgery. These tests will include:

Physical examination: The doctor will conduct some physical tests to determine whether you are fit to undergo surgery or not
Blood tests: Blood tests will determine the normal functioning of the other organs. Also, it will help the doctor know the blood group of the patient and whether blood transfusions will be required during surgery or not
Chest x-ray: The X-ray will reveal the condition, shape and size of the heart
Electrocardiogram: Electrocardiogram determines the rhythm of the heartbeat
Patients will be needed to take antibiotics before any other surgical procedure to reduce the risk of infection. Hours before the surgery, the patient will be asked not to eat or drink anything, to bathe and shave any hair off from the area where the surgery will be performed. The special dress will be provided to the patient by the medical staff to wear during the surgery.

Test and Diagnosis for VSD

The most commonly initiated tests to diagnose the possibility of the ventricular septal defect (VSD) include:

Echocardiogram: This test is performed to determine the anatomical structure of the heart, the volume of blood pumped by the heart and its pressures
Electrocardiogram: This test monitors any problems with the heart rhythm
Chest X-rays: Chest X-ray shows the size and shape of the heart
Coronary catheterization: This test identifies the blocked blood vessels
Magnetic resonance imaging (MRI): MRI takes a detailed picture of the heart’s chambers and blood vessels
Stress (exercise) testing: This test measures the functioning accuracy of the heart under stressful conditions
During the Surgery

The VSD correction surgery is performed by two methods

Intra-cardiac Technique: This is the most commonly used method for treating VSD in children. It is an open heart surgery performed when the patient is put in a heart-lung machine or the cardiopulmonary bypass. During this process, the surgeon sews a patch of fabric or a part of the pericardium present outside the heart over the VSD. This helps to close the VSD completely, and in the course of time, the patch is covered by normal tissue and recovers completely.
Catheter Intervention: In this type of surgery, it is performed through a catheter- a tube that is run through the blood vessels directly into the heart. Catheter techniques are best suited for minor or small septal defects and some defective valves.
After the heart surgery

After the successful completion of the surgery, the patient with repaired VSDs must visit a cardiologist for regular check-ups. On the contrary, those patients who develop other congenital problems or have any cardiac complications after the surgery should continue to see an adult congenital heart disease specialist.”

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2.

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Prescription

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4.

GDP Instruction

Import medicine under the GDP instruction

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

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QA check

Supply drugs to concerned healthcare provider after QA check

 

FAQ

A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient’s home country.

 

No. Companies are not required to provide their products through a formal NPP.

 

  • Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner
  • Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates
  • Providing new products to patients who would move to commercial drug when it becomes available in these countries
  • Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis

Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.

 
 

INFORMATION FOR PATIENTS

As a named patient medicines you may find yourself in the frightening position that you have a serious condition or illness and the treatment you need is not available in your home country. It is possible that the medicines are available outside your country and if your physician decides that these drugs would be suitable for the treatment of your illness, they then face the challenge of obtaining them for you. We help physicians across the world access medicines which are not approved or licensed in their country, but may be required to meet the special needs of an individual patient. The service we provide not only locates and supplies the required medicines but ensures that the physician has all the quality assurance and supporting clinical information they will need to safely prescribe it to you. If you are confronted with a situation where a drug is not available to you, talk to your physician or healthcare professional about Named Patient Program and ask them to contact us. We will then work directly with your physician to help them in patient access program and understand what options are available.

 

 

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1.

Request for medicine

Patient who has serious problem request for medicine

 

2.

Drug Verify

Internal processing of drug verifications at GM Global

 

3.

Prescription

Recognizing best source for the specific prescription

 

4.

GDP Instruction

Import medicine under the GDP instruction

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

FAQ

A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient’s home country.

 

No. Companies are not required to provide their products through a formal NPP.

 

  • Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner
  • Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates
  • Providing new products to patients who would move to commercial drug when it becomes available in these countries
  • Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis

Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.

 
 

INFORMATION FOR PATIENTS

As a named patient medicines you may find yourself in the frightening position that you have a serious condition or illness and the treatment you need is not available in your home country. It is possible that the medicines are available outside your country and if your physician decides that these drugs would be suitable for the treatment of your illness, they then face the challenge of obtaining them for you. We help physicians across the world access medicines which are not approved or licensed in their country, but may be required to meet the special needs of an individual patient. The service we provide not only locates and supplies the required medicines but ensures that the physician has all the quality assurance and supporting clinical information they will need to safely prescribe it to you. If you are confronted with a situation where a drug is not available to you, talk to your physician or healthcare professional about Named Patient Program and ask them to contact us. We will then work directly with your physician to help them in patient access program and understand what options are available.