info.3se@keehealthcare.com

Total Knee Replacement Surgery (TKR)

Knee replacement is a kind of arthroplasty that means “surgical repair of a joint” and it involves the surgical replacement and reconstruction of degenerated joints, using prosthetics or artificial body parts.

When the articular cartilage of the knee is worn out or damaged, then instead of sliding over each other, the bones crush and rub each other. This makes the knee hard to move and painful.

The surgeon caps the ends of the bones that form the knee joint with plastic or metal components or implants a prosthetic that is shaped as a joint. With a prosthetic, the patient feels less pain and the knee will move properly.

Knee replacement surgery can help patients whose knee (or knees) has degenerated due to rheumatoid arthritis, osteoarthritis, or post-traumatic arthritis when an injury has damaged the knee.

Type of knee replacement surgery

Knee replacement can be partial or total.

Total Knee Replacement (TKR)

Total knee replacement surgery is the replacement of both sides of the knee joint.

The surgery lasts between 1 to 3 hours. The individual will feel less pain and better mobility but there will be scar tissue, which can make it difficult to bend and move the knees.

Partial knee replacement (PKR)

Partial replacement includes the replacement of only one side of the knee joint. In this procedure, less bone is removed, so a smaller incision is needed but it does not last as long as a total replacement surgery.

Partial knee replacement is suitable for people whose only one part of the knee is damaged.

The recovery period and hospital stay are normally shorter as compare to the total knee replacement surgery.

What is the need for knee replacement surgery?

The three common reasons for knee replacement surgery are:

Osteoarthritis: Osteoarthritis is related to age and caused by the normal wear and tear of the knee joint. It mostly affects the patients of age above 50 years but younger people may have it.

Osteoarthritis is caused by breakdown, inflammation and the eventual and gradual loss of cartilage in the joints. Over time, the cartilage wears down and the bones start rubbing together. To compensate, the bones may grow thicker but this results in more friction that increases the pain.

Rheumatoid arthritis: It is also called inflammatory arthritis; the membrane around the knee joint becomes inflamed and thick. Chronic inflammation damages the cartilage, causing stiffness and soreness.

Post-traumatic arthritis: Post-traumatic arthritis is the result of a severe knee injury. Breaking of the bones around the knee or tearing up the ligaments affects the knee cartilage.

Who might need a knee replacement?

Knee surgery is a suitable option for patients who experience:

Severe knee pain or stiffness that prevents them from doing everyday tasks and activities such as going upstairs, walking, getting up from a chair and getting in and out of cars.
Moderate but continuous knee pain that continues even while resting or sleeping
Chronic knee swelling and inflammation that does not improve after resting or taking medications
Knee deformity, when there is a noticeable arch on the outside or inside of the knee
Depression, resulting from the inability to carry out social or daily activities.
Test and diagnosis

A complete physical examination of the patient as well as several diagnostic tests including blood tests will be done.
Medical history (such as hemophilia, diabetes, blood pressure and pregnancy), medications and drug allergies if any, should be informed to the doctor before the surgery.
The patient is advised to avoid smoking for as long as possible before the surgical procedure.
Treatment Procedure for Knee Replacement

Knee Replacement surgery procedure

Knee replacement surgery lasts up to 2-3 hours.

An intravenous (IV) line is started in your hand or arm & a urinary catheter is inserted.
The skin over the surgical site will be cleansed with an antiseptic solution.
The doctor makes an incision in the knee area.
Then, the surgeon removes the damaged knee joint surface and resurface it with the prosthesis.
The prosthesis for the knee is made up of metal and plastic. However, a cemented prosthesis is the most common type of artificial knee prosthesis; it attaches to the bone with surgical cement.
The prosthesis is mostly comprised of 3 components: the tibial component (to resurface the top of the shin or tibia bone), the femoral component (to resurface the end of the thigh bone and the patellar component (to resurface the kneecap bottom that rubs against the thigh bone).
The incision will be closed with surgical staples or stitches & a drain may be placed in the incision site to remove the fluid.
A sterile bandage or dressing will be applied.
After the Knee Replacement surgery

After the surgery, the patient is kept in the recovery room for a few hours.
The patient will be hospitalised for 4-6 days.
Most people recover within 12 months after the surgery but the recovery time will differ depending on the age and overall health.

How it works?

1.

Request for medicine

Patient who has serious problem request for medicine

 

2.

Drug Verify

Internal processing of drug verifications at GM Global

 

3.

Prescription

Recognizing best source for the specific prescription

 

4.

GDP Instruction

Import medicine under the GDP instruction

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

FAQ

A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient’s home country.

 

No. Companies are not required to provide their products through a formal NPP.

 

  • Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner
  • Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates
  • Providing new products to patients who would move to commercial drug when it becomes available in these countries
  • Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis

Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.

 
 

INFORMATION FOR PATIENTS

As a named patient medicines you may find yourself in the frightening position that you have a serious condition or illness and the treatment you need is not available in your home country. It is possible that the medicines are available outside your country and if your physician decides that these drugs would be suitable for the treatment of your illness, they then face the challenge of obtaining them for you. We help physicians across the world access medicines which are not approved or licensed in their country, but may be required to meet the special needs of an individual patient. The service we provide not only locates and supplies the required medicines but ensures that the physician has all the quality assurance and supporting clinical information they will need to safely prescribe it to you. If you are confronted with a situation where a drug is not available to you, talk to your physician or healthcare professional about Named Patient Program and ask them to contact us. We will then work directly with your physician to help them in patient access program and understand what options are available.

 

 

Drugs We Provide Under NPS

Drug Directory

Orphan Drugs

1.

Request for medicine

Patient who has serious problem request for medicine

 

2.

Drug Verify

Internal processing of drug verifications at GM Global

 

3.

Prescription

Recognizing best source for the specific prescription

 

4.

GDP Instruction

Import medicine under the GDP instruction

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

FAQ

A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient’s home country.

 

No. Companies are not required to provide their products through a formal NPP.

 

  • Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner
  • Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates
  • Providing new products to patients who would move to commercial drug when it becomes available in these countries
  • Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis

Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.

 
 

INFORMATION FOR PATIENTS

As a named patient medicines you may find yourself in the frightening position that you have a serious condition or illness and the treatment you need is not available in your home country. It is possible that the medicines are available outside your country and if your physician decides that these drugs would be suitable for the treatment of your illness, they then face the challenge of obtaining them for you. We help physicians across the world access medicines which are not approved or licensed in their country, but may be required to meet the special needs of an individual patient. The service we provide not only locates and supplies the required medicines but ensures that the physician has all the quality assurance and supporting clinical information they will need to safely prescribe it to you. If you are confronted with a situation where a drug is not available to you, talk to your physician or healthcare professional about Named Patient Program and ask them to contact us. We will then work directly with your physician to help them in patient access program and understand what options are available.