WordPress database error: [CREATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_woof_sd`]
CREATE TABLE IF NOT EXISTS `wp_woof_sd` ( `id` int(11) NOT NULL AUTO_INCREMENT, `title` text, `type` varchar(32) NOT NULL DEFAULT 'checkbox', `template` int(2) DEFAULT 0, `demo_taxonomy` varchar(96) DEFAULT '0', `options` text, PRIMARY KEY (`id`) ) DEFAULT CHARACTER SET utf8mb4 COLLATE utf8mb4_unicode_520_ci;

WordPress database error: [INSERT, UPDATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_options`]
INSERT INTO `wp_options` (`option_name`, `option_value`, `autoload`) VALUES ('_site_transient_timeout_wp_theme_files_patterns-227da78d58689016b0a410d455919329', '1760559538', 'off') ON DUPLICATE KEY UPDATE `option_name` = VALUES(`option_name`), `option_value` = VALUES(`option_value`), `autoload` = VALUES(`autoload`)

WordPress database error: [INSERT, UPDATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_options`]
INSERT INTO `wp_options` (`option_name`, `option_value`, `autoload`) VALUES ('_site_transient_wp_theme_files_patterns-227da78d58689016b0a410d455919329', 'a:2:{s:7:\"version\";s:3:\"2.9\";s:8:\"patterns\";a:0:{}}', 'off') ON DUPLICATE KEY UPDATE `option_name` = VALUES(`option_name`), `option_value` = VALUES(`option_value`), `autoload` = VALUES(`autoload`)

WordPress database error: [INSERT, UPDATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_options`]
INSERT INTO `wp_options` (`option_name`, `option_value`, `autoload`) VALUES ('_transient_timeout_as-post-store-dependencies-met', '1760644138', 'off') ON DUPLICATE KEY UPDATE `option_name` = VALUES(`option_name`), `option_value` = VALUES(`option_value`), `autoload` = VALUES(`autoload`)

WordPress database error: [INSERT, UPDATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_options`]
INSERT INTO `wp_options` (`option_name`, `option_value`, `autoload`) VALUES ('_transient_as-post-store-dependencies-met', 'yes', 'off') ON DUPLICATE KEY UPDATE `option_name` = VALUES(`option_name`), `option_value` = VALUES(`option_value`), `autoload` = VALUES(`autoload`)

WordPress database error: [UPDATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1760557738.2043929100036621093750' WHERE `option_name` = '_transient_doing_cron'

Patent Ductus Arteriosus (PDA) – Kee Healthcare

WordPress database error: [UPDATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_postmeta`]
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WordPress database error: [UPDATE command denied to user 'u282166675_khpl'@'localhost' for table `u282166675_khpl`.`wp_postmeta`]
UPDATE `wp_postmeta` SET `meta_value` = '{\"timeout\":1760644138,\"value\":{\"content\":\"\\t\\t<section class=\\\"elementor-section elementor-top-section elementor-element elementor-element-1ff9eacd elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\\\" data-id=\\\"1ff9eacd\\\" data-element_type=\\\"section\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-background-overlay\\\"><\\/div>\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-32d3b49a\\\" data-id=\\\"32d3b49a\\\" data-element_type=\\\"column\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<section class=\\\"elementor-section elementor-inner-section elementor-element elementor-element-48c2ec9a elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"48c2ec9a\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1f8c86fd\\\" data-id=\\\"1f8c86fd\\\" data-element_type=\\\"column\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-4eda1a4c elementor-widget__width-auto elementor-widget elementor-widget-heading\\\" data-id=\\\"4eda1a4c\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Patent Ductus Arteriosus (PDA)<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c9cbe3f\\\" data-id=\\\"c9cbe3f\\\" data-element_type=\\\"column\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap\\\">\\n\\t\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-top-section elementor-element elementor-element-5bb140f8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"5bb140f8\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-33047327\\\" data-id=\\\"33047327\\\" data-element_type=\\\"column\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-32a20922 elementor-widget elementor-widget-heading\\\" data-id=\\\"32a20922\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">How it works?<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-inner-section elementor-element elementor-element-7acdaacf elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"7acdaacf\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div 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class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Request for medicine<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-7def7232\\\" data-id=\\\"7def7232\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-326d3cf6 elementor-widget elementor-widget-heading\\\" data-id=\\\"326d3cf6\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title 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elementor-widget-heading\\\" data-id=\\\"408826d3\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">3.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-3045c9d7 elementor-widget elementor-widget-heading\\\" data-id=\\\"3045c9d7\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Prescription<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-inner-section elementor-element elementor-element-1995260e elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"1995260e\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-efce2c\\\" data-id=\\\"efce2c\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-133badb4 elementor-widget elementor-widget-heading\\\" data-id=\\\"133badb4\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">4.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-563b03b6 elementor-widget elementor-widget-heading\\\" data-id=\\\"563b03b6\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">GDP Instruction<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-16388186\\\" data-id=\\\"16388186\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-6fbd3204 elementor-widget elementor-widget-heading\\\" data-id=\\\"6fbd3204\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">5.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-7d12433f elementor-widget elementor-widget-heading\\\" data-id=\\\"7d12433f\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">QA check<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-15657d29\\\" data-id=\\\"15657d29\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-15f18647 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-heading\\\" data-id=\\\"15f18647\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">5.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-1305d758 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-heading\\\" data-id=\\\"1305d758\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">QA check<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-79059e6f elementor-widget elementor-widget-heading\\\" data-id=\\\"79059e6f\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">FAQ<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-24a60d9 elementor-widget elementor-widget-accordion\\\" data-id=\\\"24a60d9\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"accordion.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion\\\">\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-3841\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"1\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-3841\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\">What is a Named Patient Program (NPP)?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-3841\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"1\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-3841\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"fa86569c74c51eb91\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><p>A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient\\u2019s home country.<\\/p><\\/div><\\/div><\\/div><div class=\\\"fusion-panel panel-default\\\"><div class=\\\"panel-heading\\\"><h4 class=\\\"panel-title toggle fusion-responsive-typography-calculated\\\" data-fontsize=\\\"16\\\" data-lineheight=\\\"22.08px\\\">\\u00a0<\\/h4><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-3842\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"2\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-3842\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\"> Are companies required to have a NPP for their products?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-3842\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"2\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-3842\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"a513bd5c049b27ce5\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><p>No. Companies are not required to provide their products through a formal NPP.<\\/p><\\/div><\\/div><\\/div><div class=\\\"fusion-panel panel-default\\\"><div class=\\\"panel-heading\\\"><h4 class=\\\"panel-title toggle fusion-responsive-typography-calculated\\\" data-fontsize=\\\"16\\\" data-lineheight=\\\"22.08px\\\">\\u00a0<\\/h4><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-3843\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"3\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-3843\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\">What are the advantages to sponsors of conducting a NPP?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-3843\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"3\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-3843\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"a513bd5c049b27ce5\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><ul><li>Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner<\\/li><li>Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates<\\/li><li>Providing new products to patients who would move to commercial drug when it becomes available in these countries<\\/li><li>Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis<\\/li><\\/ul><\\/div><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-3844\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"4\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-3844\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\"> Can companies provide drug through a NPP to patients in any country?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-3844\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"4\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-3844\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"a513bd5c049b27ce5\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"accordian fusion-accordian\\\"><div id=\\\"accordion-12220-1\\\" class=\\\"panel-group\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"db1c92dbf201baa8e\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"accordian fusion-accordian\\\"><div id=\\\"accordion-12220-1\\\" class=\\\"panel-group\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"db1c92dbf201baa8e\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"accordian fusion-accordian\\\"><div id=\\\"accordion-12220-1\\\" class=\\\"panel-group\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"db1c92dbf201baa8e\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><p>Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.<\\/p><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><div class=\\\"fusion-clearfix\\\">\\u00a0<\\/div><\\/div><\\/div><\\/div><\\/div><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-2 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"fusion-text fusion-text-2\\\">\\u00a0<\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-2e5e8332 elementor-widget elementor-widget-heading\\\" data-id=\\\"2e5e8332\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">INFORMATION FOR PATIENTS\\n<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-4b92841e elementor-widget elementor-widget-heading\\\" data-id=\\\"4b92841e\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Drugs We Provide Under NPS<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-inner-section elementor-element elementor-element-5256aece elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"5256aece\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5abf339e\\\" data-id=\\\"5abf339e\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-33f7884 elementor-widget elementor-widget-heading\\\" data-id=\\\"33f7884\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Drug Directory<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-f1a0c61 elementor-view-default elementor-widget elementor-widget-icon\\\" data-id=\\\"f1a0c61\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"icon.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-icon-wrapper\\\">\\n\\t\\t\\t<div class=\\\"elementor-icon\\\">\\n\\t\\t\\t<i aria-hidden=\\\"true\\\" class=\\\"fas fa-chevron-right\\\"><\\/i>\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-47edc5ac\\\" data-id=\\\"47edc5ac\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-737222f7 elementor-widget elementor-widget-heading\\\" data-id=\\\"737222f7\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Orphan Drugs<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-21dcfdb0 elementor-view-default elementor-widget elementor-widget-icon\\\" data-id=\\\"21dcfdb0\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"icon.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-icon-wrapper\\\">\\n\\t\\t\\t<div class=\\\"elementor-icon\\\">\\n\\t\\t\\t<i aria-hidden=\\\"true\\\" class=\\\"fas fa-chevron-right\\\"><\\/i>\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d2cdf56 sticky\\\" data-id=\\\"d2cdf56\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-top-section elementor-element elementor-element-1b95696e elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"1b95696e\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-no\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-687d39b\\\" data-id=\\\"687d39b\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-4ceca3af elementor-widget elementor-widget-heading\\\" data-id=\\\"4ceca3af\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">1.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-6e11294e elementor-widget elementor-widget-heading\\\" data-id=\\\"6e11294e\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Request for medicine<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-6a432ab5\\\" data-id=\\\"6a432ab5\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-59c94074 elementor-widget elementor-widget-heading\\\" data-id=\\\"59c94074\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">2.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-61d77e64 elementor-widget elementor-widget-heading\\\" data-id=\\\"61d77e64\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Drug Verify<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-71b77aef\\\" data-id=\\\"71b77aef\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-6ae2336f elementor-widget elementor-widget-heading\\\" data-id=\\\"6ae2336f\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">3.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-6016f1ff elementor-widget elementor-widget-heading\\\" data-id=\\\"6016f1ff\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">Prescription<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-top-section elementor-element elementor-element-5560ddad elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"5560ddad\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1822f7c7\\\" data-id=\\\"1822f7c7\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-28649701 elementor-widget elementor-widget-heading\\\" data-id=\\\"28649701\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">4.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-6dd85bb elementor-widget elementor-widget-heading\\\" data-id=\\\"6dd85bb\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">GDP Instruction<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-2bf281ef\\\" data-id=\\\"2bf281ef\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-71e63ba9 elementor-widget elementor-widget-heading\\\" data-id=\\\"71e63ba9\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">5.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-5551e2fd elementor-widget elementor-widget-heading\\\" data-id=\\\"5551e2fd\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">QA check<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-183dea00\\\" data-id=\\\"183dea00\\\" data-element_type=\\\"column\\\" data-settings=\\\"{&quot;background_background&quot;:&quot;classic&quot;}\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-5b9ab677 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-heading\\\" data-id=\\\"5b9ab677\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">5.<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-4ea0c29e elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-heading\\\" data-id=\\\"4ea0c29e\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">QA check<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-top-section elementor-element elementor-element-54f1fed1 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"54f1fed1\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-560d31ec\\\" data-id=\\\"560d31ec\\\" data-element_type=\\\"column\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-699014c6 elementor-widget elementor-widget-heading\\\" data-id=\\\"699014c6\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">FAQ<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-65e734aa elementor-widget elementor-widget-accordion\\\" data-id=\\\"65e734aa\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"accordion.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion\\\">\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-1701\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"1\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-1701\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\">What is a Named Patient Program (NPP)?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-1701\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"1\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-1701\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"fa86569c74c51eb91\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><p>A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient\\u2019s home country.<\\/p><\\/div><\\/div><\\/div><div class=\\\"fusion-panel panel-default\\\"><div class=\\\"panel-heading\\\"><h4 class=\\\"panel-title toggle fusion-responsive-typography-calculated\\\" data-fontsize=\\\"16\\\" data-lineheight=\\\"22.08px\\\">\\u00a0<\\/h4><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-1702\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"2\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-1702\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\"> Are companies required to have a NPP for their products?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-1702\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"2\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-1702\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"a513bd5c049b27ce5\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><p>No. Companies are not required to provide their products through a formal NPP.<\\/p><\\/div><\\/div><\\/div><div class=\\\"fusion-panel panel-default\\\"><div class=\\\"panel-heading\\\"><h4 class=\\\"panel-title toggle fusion-responsive-typography-calculated\\\" data-fontsize=\\\"16\\\" data-lineheight=\\\"22.08px\\\">\\u00a0<\\/h4><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-1703\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"3\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-1703\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\">What are the advantages to sponsors of conducting a NPP?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-1703\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"3\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-1703\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"a513bd5c049b27ce5\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><ul><li>Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner<\\/li><li>Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates<\\/li><li>Providing new products to patients who would move to commercial drug when it becomes available in these countries<\\/li><li>Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis<\\/li><\\/ul><\\/div><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-accordion-item\\\">\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-title-1704\\\" class=\\\"elementor-tab-title\\\" data-tab=\\\"4\\\" role=\\\"button\\\" aria-controls=\\\"elementor-tab-content-1704\\\" aria-expanded=\\\"false\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon elementor-accordion-icon-left\\\" aria-hidden=\\\"true\\\">\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-closed\\\"><i class=\\\"fas fa-plus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t<span class=\\\"elementor-accordion-icon-opened\\\"><i class=\\\"fas fa-minus\\\"><\\/i><\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<\\/span>\\n\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t\\t<a class=\\\"elementor-accordion-title\\\" tabindex=\\\"0\\\"> Can companies provide drug through a NPP to patients in any country?<\\/a>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<div id=\\\"elementor-tab-content-1704\\\" class=\\\"elementor-tab-content elementor-clearfix\\\" data-tab=\\\"4\\\" role=\\\"region\\\" aria-labelledby=\\\"elementor-tab-title-1704\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"a513bd5c049b27ce5\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"accordian fusion-accordian\\\"><div id=\\\"accordion-12220-1\\\" class=\\\"panel-group\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"db1c92dbf201baa8e\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"accordian fusion-accordian\\\"><div id=\\\"accordion-12220-1\\\" class=\\\"panel-group\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"db1c92dbf201baa8e\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"accordian fusion-accordian\\\"><div id=\\\"accordion-12220-1\\\" class=\\\"panel-group\\\"><div class=\\\"fusion-panel panel-default\\\"><div id=\\\"db1c92dbf201baa8e\\\" class=\\\"panel-collapse collapse in\\\"><div class=\\\"panel-body toggle-content fusion-clearfix\\\"><p>Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.<\\/p><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><div class=\\\"fusion-clearfix\\\">\\u00a0<\\/div><\\/div><\\/div><\\/div><\\/div><div class=\\\"fusion-fullwidth fullwidth-box fusion-builder-row-2 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\\\"><div class=\\\"fusion-builder-row fusion-row\\\"><div class=\\\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\\\"><div class=\\\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\\\"><div class=\\\"fusion-column-content-centered\\\"><div class=\\\"fusion-column-content\\\"><div class=\\\"fusion-text fusion-text-2\\\">\\u00a0<\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div><\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\\t\\t<section class=\\\"elementor-section elementor-top-section elementor-element elementor-element-1617bd52 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\\\" data-id=\\\"1617bd52\\\" data-element_type=\\\"section\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-container elementor-column-gap-default\\\">\\n\\t\\t\\t\\t\\t<div class=\\\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-12bdadb7\\\" data-id=\\\"12bdadb7\\\" data-element_type=\\\"column\\\">\\n\\t\\t\\t<div class=\\\"elementor-widget-wrap elementor-element-populated\\\">\\n\\t\\t\\t\\t\\t\\t<div class=\\\"elementor-element elementor-element-47f6a467 elementor-widget elementor-widget-heading\\\" data-id=\\\"47f6a467\\\" data-element_type=\\\"widget\\\" data-widget_type=\\\"heading.default\\\">\\n\\t\\t\\t\\t<div class=\\\"elementor-widget-container\\\">\\n\\t\\t\\t\\t\\t<h2 class=\\\"elementor-heading-title elementor-size-default\\\">INFORMATION FOR PATIENTS\\n<\\/h2>\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/div>\\n\\t\\t\\t\\t\\t<\\/div>\\n\\t\\t<\\/section>\\n\\t\\t\",\"scripts\":[],\"styles\":[]}}' WHERE `post_id` = 2227 AND `meta_key` = '_elementor_element_cache'

Patent Ductus Arteriosus (PDA)

“What Is Patent Ductus Arteriosus?


Patent ductus arteriosus (PDA) is a heart problem that occurs soon after birth in some babies. In PDA, abnormal blood flow occurs between two of the major arteries connected to the heart.


Before birth, the two major arteries—the aorta and the pulmonary artery—are connected by a blood vessel called the ductus arteriosus. This vessel is an essential part of fetal blood circulation.


Within minutes or up to a few days after birth, the vessel is supposed to close as part of the normal changes occurring in the baby’s circulation.


In some babies, however, the ductus arteriosus remains open (patent). This opening allows oxygen-rich blood from the aorta to mix with oxygen-poor blood from the pulmonary artery. This can put strain on the heart and increase blood pressure in the lung arteries.
Overview


PDA is a type of congenital heart defect. A congenital heart defect is any type of heart problem that’s present at birth.


If your baby has a PDA but an otherwise normal heart, the PDA may shrink and go away. However, some children need treatment to close their PDAs.


Some children who have PDAs are given medicine to keep the ductus arteriosus open. For example, this may be done if a child is born with another heart defect that decreases blood flow to the lungs or the rest of the body.


Keeping the PDA open helps maintain blood flow and oxygen levels until doctors can do surgery to correct the other heart defect.


Outlook


PDA is a fairly common congenital heart defect in the United States. Although the condition can affect full-term infants, it’s more common in premature infants.


On average, PDA occurs in about 8 out of every 1,000 premature babies, compared with 2 out of every 1,000 full-term babies. Premature babies also are more vulnerable to the effects of PDA.


PDA is twice as common in girls as it is in boys.


Doctors treat the condition with medicines, catheter-based procedures, and surgery. Most children who have PDAs live healthy, normal lives after treatment.


How the Heart Works


To understand patent ductus arteriosus, it helps to know how a normal heart works. Your child’s heart is a muscle about the size of his or her fist. It works like a pump and beats about 100,000 times a day.


The heart has two sides, separated by an inner wall called the septum. The right side of the heart pumps blood to the lungs to pick up oxygen. Then, oxygen-rich blood returns from the lungs to the left side of the heart, and the left side pumps it to the body.


The heart has four chambers and four valves and is connected to various blood vessels. Veins are the blood vessels that carry blood from the body to the heart. Arteries are the blood vessels that carry blood away from the heart to the body.
Heart Chambers


The heart has four chambers or “”rooms.””


The atria are the two upper chambers that collect blood as it flows into the heart.
The ventricles are the two lower chambers that pump blood out of the heart to the lungs or other parts of the body.

Heart Valves


Four valves control the flow of blood from the atria to the ventricles and from the ventricles into the two large arteries connected to the heart.


The tricuspid valve is in the right side of the heart, between the right atrium and the right ventricle.
The pulmonary valve is in the right side of the heart, between the right ventricle and the entrance to the pulmonary artery. This artery carries blood from the heart to the lungs.
The mitral valve is in the left side of the heart, between the left atrium and the left ventricle.
The aortic valve is in the left side of the heart, between the left ventricle and the entrance to the aorta. This artery carries blood from the heart to the body.

Valves are like doors that open and close. They open to allow blood to flow through to the next chamber or to one of the arteries. Then they shut to keep blood from flowing backward.


When the heart’s valves open and close, they make a “”lub-DUB”” sound that a doctor can hear using a stethoscope.


The first sound—the “”lub””—is made by the mitral and tricuspid valves closing at the beginning of systole. Systole is when the ventricles contract, or squeeze, and pump blood out of the heart.
The second sound—the “”DUB””—is made by the aortic and pulmonary valves closing at the beginning of diastole. Diastole is when the ventricles relax and fill with blood pumped into them by the atria.

Arteries


The arteries are major blood vessels connected to your heart.


The pulmonary artery carries blood from the right side of the heart to the lungs to pick up a fresh supply of oxygen.
The aorta is the main artery that carries oxygen-rich blood from the left side of the heart to the body.
The coronary arteries are the other important arteries attached to the heart. They carry oxygen-rich blood from the aorta to the heart muscle, which must have its own blood supply to function.

Veins


The veins also are major blood vessels connected to your heart.


The pulmonary veins carry oxygen-rich blood from the lungs to the left side of the heart so it can be pumped to the body.
The superior and inferior vena cavae are large veins that carry oxygen-poor blood from the body back to the heart.

For more information about how a healthy heart works, go to the Health Topics How the Heart Works article. The article contains animations that show how your heart pumps blood and how your heart’s electrical system works.


The Heart With Patent Ductus Arteriosus


The ductus arteriosus is a blood vessel that connects the aorta and pulmonary artery in unborn babies. This vessel allows blood to be pumped from the right side of the heart into the aorta, without stopping at the lungs for oxygen.


While a baby is in the womb, only a small amount of his or her blood needs to go to the lungs. This is because the baby gets oxygen from the mother’s bloodstream.


After birth, the baby no longer is connected to the mother’s bloodstream. Thus, the baby’s blood must travel to his or her own lungs to get oxygen. As the baby begins to breathe on his or her own, the pulmonary artery opens to allow blood into the lungs. Normally, the ductus arteriosus closes because the infant no longer needs it.


Once the ductus arteriosus closes, blood leaving the right side of the heart no longer goes into the aorta. Instead, the blood travels through the pulmonary artery to the lungs. There, the blood picks up oxygen. The oxygen-rich blood returns to the left side of the heart and is pumped to the rest of the body.


Sometimes the ductus arteriosus remains open (patent) after birth. A PDA allows blood to flow from the aorta into the pulmonary artery and to the lungs. The extra blood flowing into the lungs strains the heart. It also increases blood pressure in the lung’s arteries.


Effects of Patent Ductus Arteriosus


Full-term infants. A small PDA might not cause any problems, but a large PDA likely will cause problems. The larger the PDA, the greater the amount of extra blood that passes through the lungs.


A large PDA that remains open for an extended time can cause the heart to enlarge, forcing it to work harder. Also, fluid can build up in the lungs.


A PDA can slightly increase the risk of infective endocarditis (IE). IE is an infection of the inner lining of the heart chambers and valves.


In PDA, increased blood flow can irritate the lining of the pulmonary artery, where the ductus arteriosus connects. This irritation makes it easier for bacteria in the bloodstream to collect and grow, which can lead to IE.


Premature infants. PDA can be more serious in premature infants than in full-term infants. Premature babies are more likely to have lung damage from the extra blood flowing from the PDA into the lungs. These infants may need to be put on ventilators. Ventilators are machines that support breathing.


Increased blood flow through the lungs also can reduce blood flow to the rest of the body. This can damage other organs, especially the intestines and kidneys.


What Are the Signs and Symptoms of Patent Ductus Arteriosus?


A heart murmur may be the only sign that a baby has patent ductus arteriosus (PDA). A heart murmur is an extra or unusual sound heard during the heartbeat. Heart murmurs also have other causes besides PDA, and most murmurs are harmless.


Some infants may develop signs or symptoms of volume overload on the heart and excess blood flow in the lungs. Signs and symptoms may include:


Fast breathing, working hard to breathe, or shortness of breath. Premature infants may need increased oxygen or help breathing from a ventilator.
Poor feeding and poor weight gain.
Tiring easily.
Sweating with exertion, such as while feeding.

How Is Patent Ductus Arteriosus Diagnosed?


In full-term infants, patent ductus arteriosus (PDA) usually is first suspected when the baby’s doctor hears a heart murmur during a regular checkup.


A heart murmur is an extra or unusual sound heard during the heartbeat. Heart murmurs also have other causes besides PDA, and most murmurs are harmless.


If a PDA is large, the infant also may develop symptoms of volume overload and increased blood flow to the lungs. If a PDA is small, it may not be diagnosed until later in childhood.


If your child’s doctor thinks your child has PDA, he or she may refer you to a pediatric cardiologist. This is a doctor who specializes in diagnosing and treating heart problems in children.


Premature babies who have PDA may not have the same signs as full-term babies, such as heart murmurs. Doctors may suspect PDA in premature babies who develop breathing problems soon after birth. Tests can help confirm a diagnosis.


Diagnostic Tests


Echocardiography


Echocardiography (echo) is a painless test that uses sound waves to create a moving picture of your baby’s heart. During echo, the sound waves bounce off your child’s heart. A computer converts the sound waves into pictures of the heart’s structures.


The test allows the doctor to clearly see any problems with the way the heart is formed or the way it’s working. Echo is the most important test available to your baby’s cardiologist to both diagnose a heart problem and follow the problem over time.


In babies who have PDA, echo shows how big the PDA is and how well the heart is responding to it. When medical treatments are used to try to close a PDA, echo is used to see how well the treatments are working.


EKG (Electrocardiogram)


An EKG is a simple, painless test that records the heart’s electrical activity. For babies who have PDA, an EKG can show whether the heart is enlarged. The test also can show other subtle changes that can suggest the presence of a PDA.


How Is Patent Ductus Arteriosus Treated?


Patent ductus arteriosus (PDA) is treated with medicines, catheter-based procedures, and surgery. The goal of treatment is to close the PDA. Closure will help prevent complications and reverse the effects of increased blood volume.


Small PDAs often close without treatment. For full-term infants, treatment is needed if the PDA is large or causing health problems. For premature infants, treatment is needed if the PDA is causing breathing problems or heart problems.


Talk with your child’s doctor about treatment options and how your family prefers to handle treatment decisions.


Medicines


Your child’s doctor may prescribe medicines to help close your child’s PDA.


Indomethacin (in-doh-METH-ah-sin) is a medicine that helps close PDAs in premature infants. This medicine triggers the PDA to constrict or tighten, which closes the opening. Indomethacin usually doesn’t work in full-term infants.


Ibuprofen also is used to close PDAs in premature infants. This medicine is similar to indomethacin.


Catheter-Based Procedures


Catheters are thin, flexible tubes that doctors use as part of a procedure called cardiac catheterization. Catheter-based procedures often are used to close PDAs in infants or children who are large enough to have the procedure.


Your child’s doctor may refer to the procedure as “”transcatheter device closure.”” The procedure sometimes is used for small PDAs to prevent the risk of infective endocarditis (IE). IE is an infection of the inner lining of the heart chambers and valves.


Your child will be given medicine to help him or her relax or sleep during the procedure. The doctor will insert a catheter in a large blood vessel in the groin (upper thigh). He or she will then guide the catheter to your child’s heart.


A small metal coil or other blocking device is passed through the catheter and placed in the PDA. This device blocks blood flow through the vessel.


Catheter-based procedures don’t require the child’s chest to be opened. They also allow the child to recover quickly.


These procedures often are done on an outpatient basis. You’ll most likely be able to take your child home the same day the procedure is done.


Complications from catheter-based procedures are rare and short term. They can include bleeding, infection, and movement of the blocking device from where it was placed.


Surgery


Surgery to correct a PDA may be done if:


A premature or full-term infant has health problems due to a PDA and is too small to have a catheter-based procedure
A catheter-based procedure doesn’t successfully close the PDA
Surgery is planned for treatment of related congenital heart defects

Often, surgery isn’t done until after 6 months of age in infants who don’t have health problems from their PDAs. Doctors sometimes do surgery on small PDAs to prevent the risk of IE.


For the surgery, your child will be given medicine so that he or she will sleep and not feel any pain. The surgeon will make a small incision (cut) between your child’s ribs to reach the PDA. He or she will close the PDA using stitches or clips.


Complications from surgery are rare and usually short term. They can include hoarseness, a paralyzed diaphragm (the muscle below the lungs), infection, bleeding, or fluid buildup around the lungs.


After Surgery


After surgery, your child will spend a few days in the hospital. He or she will be given medicine to reduce pain and anxiety. Most children go home 2 days after surgery. Premature infants usually have to stay in the hospital longer because of their other health issues.


The doctors and nurses at the hospital will teach you how to care for your child at home. They will talk to you about:


Limits on activity for your child while he or she recovers
Followup appointments with your child’s doctors
How to give your child medicines at home, if needed

When your child goes home after surgery, you can expect that he or she will feel fairly comfortable. However, you child may have some short-term pain.


Your child should begin to eat better and gain weight quickly. Within a few weeks, he or she should fully recover and be able to take part in normal activities.


Long-term complications from surgery are rare. However, they can include narrowing of the aorta, incomplete closure of the PDA, and reopening of the PDA.”

How it works?

1.

Request for medicine

Patient who has serious problem request for medicine

 

2.

Drug Verify

Internal processing of drug verifications at GM Global

 

3.

Prescription

Recognizing best source for the specific prescription

 

4.

GDP Instruction

Import medicine under the GDP instruction

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

FAQ

A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient’s home country.

 

No. Companies are not required to provide their products through a formal NPP.

 

  • Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner
  • Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates
  • Providing new products to patients who would move to commercial drug when it becomes available in these countries
  • Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis

Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.

 
 

INFORMATION FOR PATIENTS

As a named patient medicines you may find yourself in the frightening position that you have a serious condition or illness and the treatment you need is not available in your home country. It is possible that the medicines are available outside your country and if your physician decides that these drugs would be suitable for the treatment of your illness, they then face the challenge of obtaining them for you. We help physicians across the world access medicines which are not approved or licensed in their country, but may be required to meet the special needs of an individual patient. The service we provide not only locates and supplies the required medicines but ensures that the physician has all the quality assurance and supporting clinical information they will need to safely prescribe it to you. If you are confronted with a situation where a drug is not available to you, talk to your physician or healthcare professional about Named Patient Program and ask them to contact us. We will then work directly with your physician to help them in patient access program and understand what options are available.

 

 

Drugs We Provide Under NPS

Drug Directory

Orphan Drugs

1.

Request for medicine

Patient who has serious problem request for medicine

 

2.

Drug Verify

Internal processing of drug verifications at GM Global

 

3.

Prescription

Recognizing best source for the specific prescription

 

4.

GDP Instruction

Import medicine under the GDP instruction

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

5.

QA check

Supply drugs to concerned healthcare provider after QA check

 

FAQ

A NPP provides access to post-approval drugs that are approved and commercially available in one or more country, other than the patient’s home country.

 

No. Companies are not required to provide their products through a formal NPP.

 

  • Dealing with unsolicited patient request for drug in an ethical and regulatory controlled manner
  • Providing exposure to, and experience with, company products to physicians in additional countries and build a larger KOL network and future advocates
  • Providing new products to patients who would move to commercial drug when it becomes available in these countries
  • Generating additional revenues in countries that allow you to charge for drugs supplied on a named patient basis

Companies can provide drug to patients in any country in which they have not yet received marketing approval. This includes countries in which a company plans to seek marketing approval, as well as those countries in which a company does not plan to seek marketing approval.

 
 

INFORMATION FOR PATIENTS

As a named patient medicines you may find yourself in the frightening position that you have a serious condition or illness and the treatment you need is not available in your home country. It is possible that the medicines are available outside your country and if your physician decides that these drugs would be suitable for the treatment of your illness, they then face the challenge of obtaining them for you. We help physicians across the world access medicines which are not approved or licensed in their country, but may be required to meet the special needs of an individual patient. The service we provide not only locates and supplies the required medicines but ensures that the physician has all the quality assurance and supporting clinical information they will need to safely prescribe it to you. If you are confronted with a situation where a drug is not available to you, talk to your physician or healthcare professional about Named Patient Program and ask them to contact us. We will then work directly with your physician to help them in patient access program and understand what options are available.

 

 

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